Cat & Dog - Amitriptyline

Why has my veterinary surgeon prescribed this medicine?

Amitriptyline has been prescribed to treat separation anxiety in your dog or to treat excessive grooming, urine spraying and anxiety in cats. Amitriptyline is a tricyclic antidepressant.

Amitriptyline is not available as a veterinary preparation in the UK. Your veterinary surgeon may ask you to sign a consent form so a preparation licensed for humans can be used to treat your pet.

How does this medicine work?

Amitriptyline is an inhibitor of neuronal re-uptake of serotonin and norepinephrine.

How do I give this medication?

  • Give this medication to your pet as directed by your veterinary surgeon. READ THE LABEL CAREFULLY.
  • If the medicine is a liquid, measure the dose with reasonable care.
  • Try to give this medication at about the same time each day.
  • DO NOT give the pet more medicine than directed and DO NOT give more often than directed.
  • DO NOT discontinue the medication without first checking with your veterinary surgeon. Contact your veterinary surgeon in advance if your pet needs a repeat prescription.
  • Try not to miss giving any doses.
  • Wash your hands after handling the medication.
  • In case of accidental ingestion, seek medical advice immediately and show the package, leaflet or label to the physician.

What if I miss giving a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.

How do I store this medicine?

Keep this medicine out of reach of children. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

Potential side effects

  • The most often noted side effects include drowsiness, dry mouth, urine retention, and constipation, but these effects should disappear after a while. If these symptoms persist, contact your veterinary surgeon.
  • Your pet may experience a faster heart rate, some excitement, disorientation, hyperactivity and stomach upset. Notify your veterinary surgeon if symptoms are troublesome and continue.
  • Other side effects may occur. If you notice anything unusual, contact your veterinary surgeon.

Possible drug interactions

  • Make sure to tell your veterinary surgeon what other medication you are giving to your pet.
  • Quite often your veterinary surgeon may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinary surgeon may vary the dose and/or monitor your pet more closely.
  • Drugs may interact such that they can cause an increased or decreased effect or side effects. Although drug interactions may occur, it does not mean that there is necessarily a high risk of any of these occurring.
  • Contact your veterinary surgeon if your pet experiences any unusual reactions when different medications are given together.

© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Created on Jun 24, 2008.

Brunswick Place Veterinary Clinic

Brunswick Place Veterinary Clinic is a trading name of CVS (UK) Limited; a company which owns over 500 veterinary practices and is registered in England and Wales. Registered number: 03777473. Registered office: CVS House, Owen Road, Diss, Norfolk IP22 4ER.

Location Hours
Monday8:00am – 7:00pm
Tuesday8:00am – 7:00pm
Wednesday8:00am – 7:00pm
Thursday8:00am – 7:00pm
Friday8:00am – 7:00pm
Saturday9:00am – 12:00pm
SundayClosed

*Consulting Times: 9am-6:50pm M-F
From 7pm for any out of hour emergency please contact our out of hours provider: Vets Now Winchester, SO24 9BH Telephone: 01962 807565

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